This study aims to measure students' scientific literacy and collaboration skills. The method used was survey research on 267 high school students in Jakarta. The instrument in this study was a scientific literacy test of 40 multiple-choice PISA items developed by Moore and Foy (1997) and a non-test instrument in a rubric observation sheet to measure students' collaboration skills. The results show that students' scientific literacy is at a moderate level. Of 27 students, there are 3% of students with very high scientific literacy skills, 7% of students with high scientific literacy skills, 64% of students with moderate scientific literacy skills, 11% of students with low scientific literacy skills, and 15% of students with very low scientific literacy skills. The research concludes that scientific literacy is a skill that students must possess. Scientific literacy and collaboration skills are needed to face the demands of 21st-century learning with the rapid development of technology and knowledge. Keywords: scientific literacy, collaboration skill